Article
What cardiovascular defect does my prenatal mouse mutant have, and why?
Genesis (New York, N.Y. : 2000) - 1 Jan 2003
Conway Simon J, Kruzynska-Frejtag Agnieszka, Kneer Paige L, Machnicki Michal, Koushik Srinagesh V
Abstract excerpt
Since the advent of mouse targeted mutations, gene traps, an escalating use of a variety of complex transgenic manipulations, and large-scale chemical mutagenesis projects yielding many mutants with cardiovascular defects, it has become increasingly evident that defects within the heart and vascular system are largely responsible for the observed in utero lethality of the embryo and early fetus. If a...
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