Article
Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death.
Nature genetics - 1 Jul 1995
Migchielsen A A, Breuer M L, van Roon M A, te Riele H, Zurcher C, Ossendorp F, Toutain S, Hershfield M S, Berns A, Valerio D
Abstract excerpt
We report the generation and characterization of mice lacking adenosine deaminase (ADA). In humans, absence of ADA causes severe combined immunodeficiency. In contrast, ADA-deficient mice die perinatally with marked liver-cell degeneration, but lack abnormalities in the thymus. The ADA substrates, adenosine and deoxyadenosine, are increased in ADA-deficient mice. Adenine deoxyribonucleotides are only modestly...
Topics
- Adenosine Deaminase
- Animals
- Animals, Newborn
- Base Sequence
- Cell Death
- DNA Primers
- Disease Models, Animal
- Embryonic and Fetal Development
- Female
- Gene Targeting