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Article

Point mutations can inactivate in vitro and in vivo activities of p16(INK4a)/CDKN2A in human glioma.

Oncogene - 6 Feb 1997

Arap W, Knudsen E S, Wang J Y, Cavenee W K, Huang H J

Abstract excerpt

Deletions of chromosomal region 9p21 are among the most common genetic alterations observed during the clonal evolution of high grade malignant gliomas. Structural and functional evidence has suggested that homozygous deletion involving CDKN2A (the genetic locus encoding the cyclin-dependent kinase inhibitor p16(NK4a)) is a mechanism of inactivation of this gene and that it can be a growth suppressor in human...

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Identifiers

PMID: 9053859
DOI: 10.1038/sj.onc.1200870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Point mutations can inactivate in vitro and in vivo activities of p16(INK4a)/CDKN2A in human glioma.PMID 9053859Read ↗

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