Article
Point mutations can inactivate in vitro and in vivo activities of p16(INK4a)/CDKN2A in human glioma.
Oncogene - 6 Feb 1997
Arap W, Knudsen E S, Wang J Y, Cavenee W K, Huang H J
Abstract excerpt
Deletions of chromosomal region 9p21 are among the most common genetic alterations observed during the clonal evolution of high grade malignant gliomas. Structural and functional evidence has suggested that homozygous deletion involving CDKN2A (the genetic locus encoding the cyclin-dependent kina...
Topics
- Alleles
- Carrier Proteins
- Cell Cycle
- Chromosome Deletion
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p16
- Enzyme Inhibitors
- Genes, Tumor Suppressor
- Glioma
- Humans
- Phosphorylation
- Protein Biosynthesis
- Protein Kinase Inhibitors
- Recombinant Proteins
- Retinoblastoma Protein
- Transcription, Genetic
- Transfection