Article
Constitutive production of IL-6 in the anemic mice of W/Wv genotype.
Leukemia research - 1 Feb 1994
Yanai T, Sugimoto K, Tsuji T, Takashita E, Mori K J
Abstract excerpt
IL-6 was found to be produced by bone marrow cell fraction enriched for hemopoietic stem cells in response to IL-3 stimulation. To confirm the production of IL-6 by hemopoietic stem cells, we studied the response of W/Wv mouse bone marrow cells to IL-3 stimulation in terms of IL-6 production. Genetically anemic mice of W/Wv genotype are known to be depleted of normal hemopoietic stem cells. Bone marrow cells of...
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