Article
DNA binding and transcriptional properties of wild-type and mutant forms of the homeodomain protein Msx2.
Biochemical and biophysical research communications - 6 Apr 1995
Semenza G L, Wang G L, Kundu R
Abstract excerpt
Msx2 is a mammalian homeodomain protein that is expressed during craniofacial development. A proline-to-histidine substitution at residue 148 of human Msx2 results in an autosomal dominant form of craniosynostosis. In this study, both wild-type and mutant Msx2 were shown to specifically bind to a...
Topics
- Base Sequence
- DNA
- DNA-Binding Proteins
- Homeodomain Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Protein Binding
- Transcription, Genetic
- Tumor Cells, Cultured