Article
DNA binding and transcriptional properties of wild-type and mutant forms of the homeodomain protein Msx2.
Biochemical and biophysical research communications - 6 Apr 1995
Semenza G L, Wang G L, Kundu R
Abstract excerpt
Msx2 is a mammalian homeodomain protein that is expressed during craniofacial development. A proline-to-histidine substitution at residue 148 of human Msx2 results in an autosomal dominant form of craniosynostosis. In this study, both wild-type and mutant Msx2 were shown to specifically bind to a DNA sequence previously identified as a high-affinity binding site for the related homeodomain protein Msx1. In...
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