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Article

A genetic locus on Plasmodium falciparum chromosome 12 linked to a defect in mosquito-infectivity and male gametogenesis.

Molecular and biochemical parasitology - 1 Jan 1995

Vaidya A B, Muratova O, Guinet F, Keister D, Wellems T E, Kaslow D C

Abstract excerpt

Infection of mosquitoes by Plasmodium spp. requires sexual differentiation of the malarial parasite in the vertebrate host and mating of the heterogametes in the vector midgut. A Plasmodium falciparum clone, Dd2, differentiates into normal-appearing gametocytes, yet poorly infects mosquitoes. The Dd2 clone, however, effectively cross-fertilized HB3, a Central American P. falciparum clone, and yielded several...

Topics

Animals
Anopheles
Female
Genes, Protozoan
Genetic Linkage
Male
Mutation
Plasmodium falciparum
Polymorphism, Restriction Fragment Length
Spermatogenesis

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Identifiers

PMID: 7723789
DOI: 10.1016/0166-6851(94)00199-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7723789-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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