Article
A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium.
Nature - 13 Mar 2014
Sinha Abhinav, Hughes Katie R, Modrzynska Katarzyna K, Otto Thomas D, Pfander Claudia, Dickens Nicholas J, Religa Agnieszka A, Bushell Ellen, Graham Anne L, Cameron Rachael, Kafsack Bjorn F C, Williams April E, Llinas Manuel, Berriman Matthew, Billker Oliver, Waters Andrew P
Abstract excerpt
Commitment to and completion of sexual development are essential for malaria parasites (protists of the genus Plasmodium) to be transmitted through mosquitoes. The molecular mechanism(s) responsible for commitment have been hitherto unknown. Here we show that PbAP2-G, a conserved member of the apicomplexan AP2 (ApiAP2) family of DNA-binding proteins, is essential for the commitment of asexually replicating forms...
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