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A conserved malaria parasite antigen Pb22 plays a critical role in male gametogenesis inPlasmodium berghei

22 Nov 2020

Abstract excerpt

Gametogenesis, the formation of gametes from gametocytes, an essential step for malaria parasite transmission, is targeted by transmission-blocking drugs and vaccines. We identified a conserved protein (PBANKA_0305900) in Plasmodium berghei, which encodes a protein of 22 kDa (thus named Pb22) and is expressed in both asexual stages and gametocytes. Its homologues are present in all Plasmodium species and its...

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PMID: 33222390
DOI: 10.1111/cmi.13294

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