Article
Mutation of the cytoplasmic domain of the integrin beta 3 subunit. Differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis.
The Journal of biological chemistry - 21 Apr 1995
Ylänne J, Huuskonen J, O'Toole T E, Ginsberg M H, Virtanen I, Gahmberg C G
Abstract excerpt
The cytoplasmic domain of the beta subunit of the alpha IIb beta 3 integrin is required for cell spreading on fibrinogen. Here we report that deletion of six amino acids from the COOH terminus of the beta 3 (I757TYRGT) totally abolished cell spreading and formation of adhesion plaques, whereas re...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- CHO Cells
- Cell Adhesion
- Cricetinae
- Cytoplasm
- Endocytosis
- Integrin beta3
- Integrins
- Molecular Sequence Data
- Mutation
- Phagocytosis
- Structure-Activity Relationship