Article
Silver as a probe of pore-forming residues in a potassium channel.
Science (New York, N.Y.) - 14 Apr 1995
Lü Q, Miller C
Abstract excerpt
In voltage-dependent potassium channels, the molecular determinants of ion selectivity are found in the P (pore) region, a stretch of 21 contiguous residues. Cysteine was introduced at each P region position in a Shaker potassium channel. Residues projecting side chains into the pore were identif...
Topics
- Animals
- Cysteine
- Mutation
- Oocytes
- Patch-Clamp Techniques
- Potassium Channels
- Shaker Superfamily of Potassium Channels
- Silver
- Xenopus laevis