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Article

Analysis of the multiple roles of gld-1 in germline development: interactions with the sex determination cascade and the glp-1 signaling pathway.

Genetics - 1 Feb 1995

Francis R, Maine E, Schedl T

Abstract excerpt

The Caenorhabditis elegans gene gld-1 is essential for oocyte development; in gld-1 (null) hermaphrodites, a tumor forms where oogenesis would normally occur. We use genetic epistasis analysis to demonstrate that tumor formation is dependent on the sexual fate of the germline. When the germline sex determination pathway is set in the female mode (terminal fem/fog genes inactive), gld-1 (null) germ cells exit...

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Identifiers

PMID: 7713420
DOI: 10.1093/genetics/139.2.607
PMCID: PMC1206369

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