Analysis of the multiple roles of gld-1 in germline development: interactions with the sex determination cascade and the glp-1 signaling pathway.

doi:10.1093/genetics/139.2.607

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Article

Analysis of the multiple roles of gld-1 in germline development: interactions with the sex determination cascade and the glp-1 signaling pathway.

Genetics - 1 Feb 1995

Francis R, Maine E, Schedl T

Abstract excerpt

The Caenorhabditis elegans gene gld-1 is essential for oocyte development; in gld-1 (null) hermaphrodites, a tumor forms where oogenesis would normally occur. We use genetic epistasis analysis to demonstrate that tumor formation is dependent on the sexual fate of the germline. When the germline s...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Division
Disorders of Sex Development
Epistasis, Genetic
Female
Genes, Helminth
Genes, Tumor Suppressor
Germ Cells
Germinoma
Helminth Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Meiosis

Membrane Glycoproteins

Mutation

Oogenesis

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 7713420
DOI: 10.1093/genetics/139.2.607
PMCID: PMC1206369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7713420-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Analysis of the multiple roles of gld-1 in germline development: interactions with the sex determination cascade and the glp-1 signaling pathway.PMID 7713420Read ↗

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