Article
gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans.
Genetics - 1 Feb 1995
Francis R, Barton M K, Kimble J, Schedl T
Abstract excerpt
We have characterized 31 mutations in the gld-1 (defective in germline development) gene of Caenorhabditis elegans. In gld-1 (null) hermaphrodites, oogenesis is abolished and a germline tumor forms where oocyte development would normally occur. By contrast, gld-1 (null) males are unaffected. The...
Topics
- Animals
- Caenorhabditis elegans
- Disorders of Sex Development
- Genes, Dominant
- Genes, Helminth
- Genes, Tumor Suppressor
- Genetic Complementation Test
- Germ Cells
- Germinoma
- Male
- Meiosis
- Mitosis
- Mutation
- Oogenesis
- Phenotype
- Sex Differentiation
- Spermatogenesis