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Article

Genotoxic potential of quinolone antimicrobials in the in vitro comet assay and micronucleus test.

Mutation research - 28 Feb 2006

Itoh Tadashi, Mitsumori Kunitoshi, Kawaguchi Satomi, Sasaki Yu F

Abstract excerpt

The purpose of this study was to examine the genotoxicity of quinolone antimicrobials. We investigated the genotoxic potential of eight quinolones, namely nalidixic acid (NA), pipemidic acid (PPA), oxolinic acid (OA), piromidic acid (PA), enoxacin (ENX), ofloxacin (OFLX), norfloxacin (NFLX) and ciprofloxacin (CPFX), by the in vitro alkaline single-cell gel electrophoresis (comet) assay at pH>13. WTK-1 cells...

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Identifiers

PMID: 16384725
DOI: 10.1016/j.mrgentox.2005.11.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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