Specific changes in the M1 protein during adaptation of influenza virus to mouse.

doi:10.1007/BF01309872

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Article

Specific changes in the M1 protein during adaptation of influenza virus to mouse.

Archives of virology - 1 Jan 1995

Ward A C

Abstract excerpt

The matrix (M) gene of influenza virus has been implicated as a determinant of virulence for mouse brain and lung. Comparison of the M gene sequences of the mouse brain adapted variants A/NWS/33 and A/WSN/33 to their parent, A/WS/33, identified two specific amino acid substitutions in the M1 prot...

Topics

Adaptation, Physiological
Animals
Brain
Genes, Viral
Influenza A virus
Mice
Molecular Sequence Data
Mutation
Reassortant Viruses
Viral Matrix Proteins
Virulence

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