Mutations in the hemagglutinin and matrix genes of a virulent influenza virus variant, A/FM/1/47-MA, control different stages in pathogenesis.

doi:10.1016/0168-1702(96)01329-9

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Article

Mutations in the hemagglutinin and matrix genes of a virulent influenza virus variant, A/FM/1/47-MA, control different stages in pathogenesis.

Virus research - 1 Oct 1996

Smeenk C A, Wright K E, Burns B F, Thaker A J, Brown E G

Abstract excerpt

The mouse adapted strain of influenza A/FM/1/47 virus, FM-MA, has increased virulence due to mutations in HA, M1 and at least one other, unmapped, genome segment. Genetic reassortants that differ due to the HA or M1 mutations were used to define the role of these mutations in pathogenesis. Pathol...

Topics

Animals
Chromosome Mapping
Flow Cytometry
Fluorescent Antibody Technique
Hemagglutination Inhibition Tests
Hemagglutinin Glycoproteins, Influenza Virus
Humans
Hydrogen-Ion Concentration
Hypothermia
Influenza A virus
Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrophages

Membrane Fusion

Mutation

RNA-Dependent RNA Polymerase

Viral Matrix Proteins

Viral Proteins

Virulence

Source

Open in PubMed

Identifiers

PMID: 8879138
DOI: 10.1016/0168-1702(96)01329-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8879138-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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