The influenza virus variant A/FM/1/47-MA possesses single amino acid replacements in the hemagglutinin, controlling virulence, and in the matrix protein, controlling virulence as well as growth.

Abstract excerpt

Genetic analysis of mouse-adapted influenza virus variant A/FM/1/47 (FM) MA has previously identified four genome segments, 4, 5, 7, and 8, that are statistically associated with virulence. On sequencing these genome segments, we found single amino acid replacements at amino acid 47 of the HA2 su...

Topics

• Animals
• Base Sequence
• Cells, Cultured
• Dogs
• Genetic Variation
• Hemagglutinin Glycoproteins, Influenza Virus
• Hemagglutinins, Viral
• Influenza A virus
• Mice
• Molecular Sequence Data
• Species Specificity
• Viral Matrix Proteins
• Virulence
• Virus Replication