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Article

Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells.

Cancer gene therapy - 1 May 2009

Symes J C, Siatskas C, Fowler D H, Medin J A

Abstract excerpt

Adoptively transferred T cells possess anticancer activities partially mediated by T-cell FasL engagement of Fas tumor targets. However, antigen-induced T-cell activation and clonal expansion, which stimulates FasL activity, is often inefficient in tumors. As a gene therapy approach to overcome t...

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Identifiers

PMID: 19096446
DOI: 10.1038/cgt.2008.96
PMCID: PMC2857530

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19096446-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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