Article
Molecular evolution of the F glycoprotein of human parainfluenza virus type 1.
The Journal of infectious diseases - 1 Apr 1995
Ambrose M R, Hetherington S V, Watson A S, Scroggs R A, Portner A
Abstract excerpt
Human parainfluenza virus type 1 (hPIV1) is a major cause of upper and lower respiratory tract infections among children. Immunity is mediated at least in part by antibody to the fusion (F) surface glycoprotein. Thus, genetic variation in the F gene could influence host range, virulence, and immunity. To examine the genetic diversity among hPIV1 isolates, the F genes of hPIV1 isolates from a single geographic...
Topics
- Amino Acid Sequence
- Antigenic Variation
- Base Sequence
- Biological Evolution
- Cell Fusion
- Cell Line
- Conserved Sequence
- Genes, Viral
- Genetic Variation
- HN Protein
- Humans
