Structural analysis of mutations in the Drosophila beta 2-tubulin isoform reveals regions in the beta-tubulin molecular required for general and for tissue-specific microtubule functions.

Abstract excerpt

We have determined the lesions in a number of mutant alleles of beta Tub85D, the gene that encodes the testis-specific beta 2-tubulin isoform in Drosophila melanogaster. Mutations responsible for different classes of functional phenotypes are distributed throughout the beta 2-tubulin molecule. There is a telling correlation between the degree of phylogenetic conservation of the altered residues and the number of...

Topics

• Amino Acid Sequence
• Animals
• Base Sequence
• Conserved Sequence
• Drosophila melanogaster
• Flagella
• Genetic Complementation Test
• Male
• Microtubules
• Models, Biological
• Molecular Sequence Data