Article
Mutations in a beta-tubulin disrupt spindle orientation and microtubule dynamics in the early Caenorhabditis elegans embryo.
Molecular biology of the cell - 1 Nov 2003
Wright Amanda J, Hunter Craig P
Abstract excerpt
The early Caenorhabditis elegans embryo contains abundant transcripts for two alpha- and two beta-tubulins, raising the question of whether each isoform performs specialized functions or simply contributes to total tubulin levels. Our identification of two recessive, complementing alleles of a beta-tubulin that disrupt nuclear-centrosome centration and rotation in the early embryo originally suggested that this...
Topics
- Alleles
- Anaphase
- Animals
- Benomyl
- Caenorhabditis elegans
- Centrosome
- Embryo, Nonmammalian
- Microtubules
- Mutation
- RNA, Small Interfering
- Spindle Apparatus
- Tubulin