T-maze spontaneous alternation rate is decreased in S100 beta transgenic mice.

doi:10.1037//0735-7044.108.1.100

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Article

T-maze spontaneous alternation rate is decreased in S100 beta transgenic mice.

Behavioral neuroscience - 1 Feb 1994

Gerlai R, Marks A, Roder J

Abstract excerpt

S100 beta, a calcium-binding brain specific protein, may affect both brain development and hippocampal long-term potentiation. S100 beta levels are elevated in Down syndrome (DS), and the gene for S100 beta is located on chromosome 21, which is duplicated in DS. To test the hypothesis that, elevated levels of S100 beta cause behavioral alterations in a mammalian system, 3 transgenic mouse lines with multiple...

Topics

Animals
Brain
Chromosomes, Human, Pair 21
Discrimination Learning
Female
Genotype
Hippocampus
Humans
Long-Term Potentiation
Male
Mental Recall
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Transgenic

Nerve Growth Factors

Orientation

S100 Calcium Binding Protein beta Subunit

S100 Proteins

Source

Open in PubMed

Identifiers

PMID: 8192834
DOI: 10.1037//0735-7044.108.1.100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8192834-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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