Article
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors.
Nature - 6 Apr 1995
Condra J H, Schleif W A, Blahy O M, Gabryelski L J, Graham D J, Quintero J C, Rhodes A, Robbins H L, Roth E, Shivaprakash M
Abstract excerpt
Inhibitors of the human immunodeficiency virus type 1 (HIV-1) protease have entered clinical study as potential therapeutic agents for HIV-1 infection. The clinical efficacy of HIV-1 reverse transcriptase inhibitors has been limited by the emergence of resistant viral variants. Similarly, variants expressing resistance to protease inhibitors have been derived in cell culture. We now report the characterization of...
Topics
- Base Sequence
- Cell Line
- DNA Primers
- Drug Resistance, Microbial
- Drug Resistance, Multiple
- Drug Therapy, Combination
- HIV Infections
- HIV Protease Inhibitors
- HIV-1
- HeLa Cells
- Humans