Article
In vitro antiviral activity and cross-resistance profile of PL-100, a novel protease inhibitor of human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy - 1 Nov 2007
Dandache Serge, Sévigny Guy, Yelle Jocelyn, Stranix Brent R, Parkin Neil, Schapiro Jonathan M, Wainberg Mark A, Wu Jinzi J
Abstract excerpt
Despite the success of highly active antiretroviral therapy, the current emergence and spread of drug-resistant variants of human immunodeficiency virus (HIV) stress the need for new inhibitors with distinct properties. We designed, produced, and screened a library of compounds based on an original l-lysine scaffold for their potentials as HIV type 1 (HIV-1) protease inhibitors (PI). One candidate compound,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.