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Article

Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations.

Journal of virology - 1 Nov 2003

Fikkert Valery, Van Maele Bénédicte, Vercammen Jo, Hantson Anke, Van Remoortel Barbara, Michiels Martine, Gurnari Cristina, Pannecouque Christophe, De Maeyer Marc, Engelborghs Yves, De Clercq Erik, Debyser Zeger, Witvrouw Myriam

Abstract excerpt

The diketo acid L-708,906 has been reported to be a selective inhibitor of the strand transfer step of the human immunodeficiency virus type 1 (HIV-1) integration process (D. Hazuda, P. Felock, M. Witmer, A. Wolfe, K. Stillmock, J. A. Grobler, A. Espeseth, L. Gabryelski, W. Schleif, C. Blau, and M. D. Miller, Science 287:646-650, 2000). We have now studied the development of antiviral resistance to L-708,906 by...

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Identifiers

PMID: 14557631
DOI: 10.1128/jvi.77.21.11459-11470.2003
PMCID: PMC229256

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Source receipt: pubmed, retrieved 7 Sept 2026.

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