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Article

Ca2+ binding to calmodulin and its role in Schizosaccharomyces pombe as revealed by mutagenesis and NMR spectroscopy.

The Journal of biological chemistry - 1 Sept 1995

Moser M J, Lee S Y, Klevit R E, Davis T N

Abstract excerpt

As a first step toward identifying the important structural elements of calmodulin from Schizosaccharomyces pombe, we examined the ability of heterologous calmodulins and Ca(2+)-binding site mutant S. pombe calmodulins to replace the essential cam1+ gene. A cDNA encoding vertebrate calmodulin allows growth of S. pombe. However, calmodulin from Saccharomyces cerevisiae does not support growth even though the...

Read the complete abstract on PubMed

Topics

Alleles
Amino Acid Sequence
Binding Sites
Calcium
Calmodulin
Cloning, Molecular
Escherichia coli

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Magnetic Resonance Spectroscopy

Models, Molecular

Mutagenesis, Site-Directed

Phenotype

Plasmids

Point Mutation

Protein Conformation

Recombinant Proteins

Schizosaccharomyces

Temperature

Source

Identifiers

PMID: 7657644
DOI: 10.1074/jbc.270.35.20643

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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