Article
Analysis of potential functional regions using local degeneracy: mutational hotspots in human factor IX are localized in high-degeneracy regions.
Analytical biochemistry - 15 Nov 1994
Xu J, Chen R, Xiao Z X
Abstract excerpt
To study the relationship between the potential functional regions with the primary amino acid sequence, we introduced a new factor termed local degeneracy to analyze the degree of the degeneracy in a given segment of the protein. Using the defined local degeneracy, we have analyzed the human coagulation Factor IX (Christmas factor) which is an essential component of the clotting cascade. The mutational hotspots...
Topics
- Animals
- Cattle
- Factor IX
- Humans
- Mutation