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Article

Protein residue network analysis reveals fundamental properties of the human coagulation factor VIII.

Scientific reports - 16 Jun 2021

Lopes Tiago J S, Rios Ricardo, Nogueira Tatiane, Mello Rodrigo F

Abstract excerpt

Hemophilia A is an X-linked inherited blood coagulation disorder caused by the production and circulation of defective coagulation factor VIII protein. People living with this condition receive either prophylaxis or on-demand treatment, and approximately 30% of patients develop inhibitor antibodies, a serious complication that limits treatment options. Although previous studies performed targeted mutations to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34135429
DOI: 10.1038/s41598-021-92201-3
PMCID: PMC8209229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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