Immortalization of mouse intestinal epithelial cells by the SV40-large T gene. Phenotypic and immune characterization of the MODE-K cell line.

doi:10.1016/0022-1759(93)90329-6

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Immortalization of mouse intestinal epithelial cells by the SV40-large T gene. Phenotypic and immune characterization of the MODE-K cell line.

Journal of immunological methods - 5 Nov 1993

Vidal K, Grosjean I, evillard J P, Gespach C, Kaiserlian D

Abstract excerpt

Intestinal epithelial cells from the mouse small intestine were immortalized by SV40 large T gene transfer through a murine ecotropic virus. The resulting cell lines expressed the SV40 large T mRNA and exhibited morphological and phenotypic characteristics of normal enterocytes, including interce...

Topics

Animals
Antigen-Presenting Cells
Antigens, Viral, Tumor
Cell Division
Cell Line
Cell Transformation, Viral
Epithelial Cells
Epithelium
Gene Expression
Histocompatibility Antigens Class II
Intestine, Small

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Keratins

Mice

Microscopy, Electron

Phenotype

RNA, Messenger

Receptors, Vasoactive Intestinal Peptide

Simian virus 40

Source

Open in PubMed

Identifiers

PMID: 7693823
DOI: 10.1016/0022-1759(93)90329-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7693823-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immortalization of mouse intestinal epithelial cells by the SV40-large T gene. Phenotypic and immune characterization of the MODE-K cell line.PMID 7693823Read ↗

Transimmortalized mouse intestinal cells (m-ICc12) that maintain a crypt phenotype.Semantic proximity Read ↗

Cytolytic and IFN-gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are T cell receptor-beta-chain dependent.Semantic proximity Read ↗

Immortalization of epithelial cells.Semantic proximity Read ↗

Failure of T cell receptor V beta negative selection in murine intestinal intra-epithelial lymphocytes.Semantic proximity Read ↗

Gastrointestinal cancer-associated fibroblasts expressing Junctional Adhesion Molecule-A are amenable to infection by oncolytic reovirusSemantic proximity Read ↗

Conditionally immortalized colonic epithelial cell line from a Ptk6 null mouse that polarizes and differentiates in vitro.Semantic proximity Read ↗

Phenotype and TCR gamma delta variable gene repertoire of intestinal intraepithelial lymphocytes in wild mice (Mus musculus domesticus): abundance of V gamma 1 transcripts and extensive delta gene diversity.Semantic proximity Read ↗

Establishment of mouse intestinal myofibroblast cell lines.Semantic proximity Read ↗

Intestinal Intraepithelial Lymphocyte γδ-T Cell-Derived Keratinocyte Growth Factor Modulates Epithelial Growth in the MouseSemantic proximity Read ↗

Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.Semantic proximity Read ↗

Human thymic epithelial cells are frequently transformed by retroviral vectors encoding simian virus 40.Semantic proximity Read ↗

Cell culture modeling of specialized tissue: identification of genes expressed specifically by follicle-associated epithelium of Peyer's patch by expression profiling of Caco-2/Raji co-culturesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.