Effect of DNA-repair enzymes on mutagenesis by oxygen free radicals.

doi:10.1016/0027-5107(93)90068-q

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Article

Effect of DNA-repair enzymes on mutagenesis by oxygen free radicals.

Mutation research - 1 Oct 1993

Reid T M, Loeb L A

Abstract excerpt

Cytosine to thymine transitions are among the most common types of mutations produced by oxygen damage to DNA. One possible mechanism for these transitions is deamination of cytosine to uracil. Using both a forward mutation assay as well as a reversion assay specific for damage to cytosines we show that direct deamination to uracil does not play a significant role in mutagenesis induced by reactive oxygen free...

Topics

Cytosine
DNA Glycosylases
DNA Repair
DNA, Bacterial
DNA, Single-Stranded
Deamination
Deoxyribonuclease (Pyrimidine Dimer)
Electrophoresis, Agar Gel
Endodeoxyribonucleases
Escherichia coli
Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Free Radicals

Mutagenesis

Mutation

N-Glycosyl Hydrolases

Reactive Oxygen Species

Sodium Hydroxide

Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 7690886
DOI: 10.1016/0027-5107(93)90068-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7690886-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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