Article
The M gamma chain of human fetal hemoglobin is an A gamma chain with an in vitro modification of gamma 141 leucine to hydroxyleucine.
Journal of chromatography - 23 Jul 1993
Wilson J B, Brennan S O, Allen J, Shaw J G, Gu L H, Huisman T H
Abstract excerpt
We have reanalyzed the structure of the gamma T-15 peptide from the minor M gamma chain of human hemoglobin (Hb) F. Amino acid analysis confirmed that the Leu 141 residue was missing from position 9 of this peptide, and liquid secondary ion mass spectrometry indicated that it was replaced, not by methionine (residue mass 131) as previously believed, but by an amino acid of mass 129. By analogy with the recently...
Topics
- Adult
- Amino Acids
- Chromatography, High Pressure Liquid
- Fetal Hemoglobin
- Hemoglobins, Abnormal
- Humans
- Leucine
- Mutation
- Oxidation-Reduction
- Peptide Mapping
- Sickle Cell Trait