Article
Hemoglobin Terre Haute arginine beta 106. A posthumous correction to the original structure of hemoglobin Indianapolis.
The Journal of biological chemistry - 25 Mar 1991
Coleman M B, Steinberg M H, Adams J G
Abstract excerpt
The initial report of Hb Indianapolis described two affected individuals with the phenotype of severe beta-thalassemia that was dominantly inherited. The structure of this variant could not be deduced by standard techniques because of its extreme instability. Because of this limitation, the structure was ascertained by analysis of the abnormal globin chain, which had been radioactively labeled. These studies...
Topics
- Arginine
- Base Sequence
- DNA
- Electrophoresis, Polyacrylamide Gel
- Globins
- Hemoglobins, Abnormal
- Humans
- Molecular Sequence Data
- Mutation
- Phenotype
- Polymerase Chain Reaction