Article
[The molecular mechanism of the action of antiviral preparations in the adamantane series].
Vestnik Rossiiskoi akademii meditsinskikh nauk - 1 Jan 1993
Kiselev O I, Blinov V M, Kozeletskaia K N, Il'enko V I, Platonov V G, Chupakhin O N, Stukova M A, Karginov V A
Abstract excerpt
Regions of possible interaction between remantadine and transmembrane M2 protein are revealed by analysis of amino acid substitutions in remantadine- and deutiforin-resistant influenza viruses. The major region includes 5-6 amino acid residues at position 25-31, partially involving the premembrane region and the first position of a hydrophobic membrane-associated domain. The proposed model action of remantadine...
Topics
- Adamantane
- Amino Acid Sequence
- Antiviral Agents
- Base Sequence
- Drug Resistance, Microbial
- Genes, Viral
- Influenza A virus
- Models, Molecular
- Molecular Sequence Data
- Mutation