Article
[Prevention of the formation of a mutant influenza A virus resistant to rimantadine (alpha-methyl-1-adamantanemethylamine hydrochloride) by using ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide)].
Voprosy virusologii - 1 Jan 2000
Pushkarskaia N L, L'vov N D, Galegov G A
Abstract excerpt
The paper presents the results of the studies on the possibility of the development of influenza A virus resistance to effective anti-influenza drugs remantadine and ribavirine in serial passages in cell culture. Influenza virus forms resistant to remantadine were shown to develop quite rapidly....
Topics
- Adamantane
- Animals
- Chick Embryo
- Dose-Response Relationship, Drug
- Drug Resistance, Microbial
- Influenza A virus
- Mutation
- Ribavirin
- Ribonucleosides
- Rimantadine
- Virus Cultivation
- Virus Replication