Article
Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.
The EMBO journal - 1 Jul 1993
Werner S, Weinberg W, Liao X, Peters K G, Blessing M, Yuspa S H, Weiner R L, Williams L T
Abstract excerpt
In this study we used a dominant-negative FGF receptor mutant to block FGF function in a specific tissue of transgenic mice. The mutant receptor, which is known to block signal transduction in cells when co-expressed with wild-type receptors, was targeted to suprabasal keratinocytes using a kerat...
Topics
- Animals
- Cell Differentiation
- Cell Division
- Cloning, Molecular
- Ear
- Epidermal Cells
- Epidermis
- Female
- Fibroblast Growth Factors
- Genes, Dominant
- Keratinocytes
- Keratins
- Mice
- Mice, Transgenic
- Mutation