Article
Familial dysbetalipoproteinemia associated with apolipoprotein E3-Leiden in an extended multigeneration pedigree.
The Journal of clinical investigation - 1 Aug 1991
de Knijff P, van den Maagdenberg A M, Stalenhoef A F, Leuven J A, Demacker P N, Kuyt L P, Frants R R, Havekes L M
Abstract excerpt
By the careful screening of familial dysbetalipoproteinemic (FD) patients, five probands showing heterozygosity for the APOE*3-Leiden allele were found. Genealogical studies revealed that these probands share common ancestry in the 17th century. In a group of 128 family members, spanning three generations, 37 additional heterozygous APOE*3-Leiden gene carriers were detected. Although with a variable degree of...
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