Article
Retinoid status controls the appearance of reserve cells and keratin expression in mouse cervical epithelium.
Cancer research - 15 May 1993
Darwiche N, Celli G, Sly L, Lancillotti F, De Luca L M
Abstract excerpt
We describe an animal model to induce the histogenesis of squamous metaplasia of the cervical columnar epithelium, a condition usually preceding cervical neoplasia. This model is based on dietary retinoid depletion in female mice. Control sibling mice fed the same diet but with all-trans-retinoic acid (at 3 micrograms/g diet) showed the normal endocervical epithelial and glandular columnar morphology, typical of...
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