Role of Reserve Cells in Metaplasia and the Development of Human Papillomavirus–Associated High-Grade Squamous Intraepithelial Lesions at the Cervical Transformation Zone

Abstract excerpt

Squamous cervical cancers generally arise as a result of persistent infection with high-risk human papillomaviruses (hrHPVs) and occur near the squamocolumnar junction (SCJ) and within the transformation zone (TZ). The susceptibility of the TZ to HPV-related carcinogenesis appears linked to epithelial cell plasticity, with squamous metaplasia originating from a specialized stem cell population at this site. Two...

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