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Article

Requirement for Estrogen Receptor α in a Mouse Model for Human Papillomavirus–Associated Cervical Cancer

1 Dec 2008

Abstract excerpt

The majority of human cervical cancers are associated with the high-risk human papillomaviruses (HPV), which encode the potent E6 and E7 oncogenes. On prolonged treatment with physiologic levels of exogenous estrogen, K14E7 transgenic mice expressing HPV-16 E7 oncoprotein in their squamous epithelia succumb to uterine cervical cancer. Furthermore, prolonged withdrawal of exogenous estrogen results in complete or...

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PMID: 19047174
DOI: 10.1158/0008-5472.can-08-2051

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Requirement for Estrogen Receptor α in a Mouse Model for Human Papillomavirus–Associated Cervical CancerPMID 19047174Read ↗

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