5-Aza-2'-deoxycytidine: cell differentiation and DNA methylation.

Article

5-Aza-2'-deoxycytidine: cell differentiation and DNA methylation.

Leukemia - 1 May 1993

Taylor S M

Abstract excerpt

5-Azacytidine (5-aza-CR) and 5-aza-2'-deoxycytidine (5-aza-CdR), analogs of cytidine modified in position 5, were originally developed as antitumor agents, and have been useful in the treatment of both childhood and adult leukemias. These agents are cytotoxic per se, but also induce differentiati...

Topics

Antineoplastic Agents
Azacitidine
Cartilage
Cell Differentiation
Cell Line
DNA
Decitabine
Gene Expression Regulation
Methylation
Muscle Proteins
MyoD Protein
Phenotype

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