Article
Sequential changes in genome-wide DNA methylation status during adipocyte differentiation.
Biochemical and biophysical research communications - 8 Feb 2008
Sakamoto Hideki, Kogo Yasushi, Ohgane Jun, Hattori Naka, Yagi Shintaro, Tanaka Satoshi, Shiota Kunio
Abstract excerpt
DNA methylation is an epigenetic mark on the mammalian genome. There are numerous tissue-dependent and differentially methylated regions (T-DMRs) in the unique sequences distributed throughout the genome. To determine the epigenetic changes during adipocyte differentiation, we investigated the sequential changes in DNA methylation status of 3T3-L1 cells at the growing, confluent, postconfluent and mature...
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