CD20 is physically and functionally coupled to MHC class II and CD40 on human B cell lines

Abstract excerpt

Engagement of MHC class II and CD40 on B cell lines triggers intracellular signals that activates cell surface adhesion receptors, resulting in LFA-1-dependent and -independent cell-cell adhesion. In this study, a murine monoclonal antibody (mAb R21) has been produced against a LFA-1-negative human B cell line and proven to completely block MHC class II- and CD40-induced LFA-1-independent homotypic adhesion....

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• Share to Cell Adhesion Molecules Research
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