Variations in the distribution, frequency, and phenotype of Langerhans cells during the evolution of malignant melanoma of the skin.

doi:10.1111/1523-1747.ep12470135

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Article

Variations in the distribution, frequency, and phenotype of Langerhans cells during the evolution of malignant melanoma of the skin.

The Journal of investigative dermatology - 1 Mar 1993

Toriyama K, Wen D R, Paul E, Cochran A J

Abstract excerpt

We examined the frequency, distribution, and immunophenotype (S-100 protein, CD1) of epidermal Langerhans cells (LC) in the epidermis overlying primary melanoma, and dermal dendritic cells (DC) in the dermis deep to melanoma, and in adjacent normal skin. There is a substantial reduction in S-100+...

Topics

Antigens, CD
Antigens, CD1
Dendritic Cells
Humans
Langerhans Cells
Melanoma
Phenotype
S100 Proteins
Skin

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