Article
BRAFV600E mutant protein is expressed in cells of variable maturation in Langerhans cell histiocytosis.
Blood - 20 Sept 2012
Sahm Felix, Capper David, Preusser Matthias, Meyer Jochen, Stenzinger Albrecht, Lasitschka Felix, Berghoff Anna-Sophie, Habel Antje, Schneider Marion, Kulozik Andreas, Anagnostopoulos Ioannis, Müllauer Leonhard, Mechtersheimer Gunhild, von Deimling Andreas
Abstract excerpt
Langerhans cell histiocytosis (LCH) is a clinically and histologically heterogeneous disorder. Its classification as either reactive inflammatory or neoplastic has been a matter of debate. However, the recent finding of frequent BRAFV600E mutations in LCH argues for the latter. The exact cell type that harbors the mutation and is responsible for proliferation remains to be identified. We here apply a BRAFV600E...
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