Article
BRAFV600E mutant protein is expressed in cells of variable maturation in Langerhans cell histiocytosis.
Blood - 20 Sept 2012
Sahm Felix, Capper David, Preusser Matthias, Meyer Jochen, Stenzinger Albrecht, Lasitschka Felix, Berghoff Anna-Sophie, Habel Antje, Schneider Marion, Kulozik Andreas, Anagnostopoulos Ioannis, Müllauer Leonhard, Mechtersheimer Gunhild, von Deimling Andreas
Abstract excerpt
Langerhans cell histiocytosis (LCH) is a clinically and histologically heterogeneous disorder. Its classification as either reactive inflammatory or neoplastic has been a matter of debate. However, the recent finding of frequent BRAFV600E mutations in LCH argues for the latter. The exact cell typ...
Topics
- Biomarkers
- Blotting, Western
- Cells, Cultured
- DNA
- Fluorescent Antibody Technique
- Histiocytosis, Langerhans-Cell
- Humans
- Immunoenzyme Techniques
- Mutant Proteins
- Mutation
- Polymerase Chain Reaction
- Proto-Oncogene Proteins B-raf