Article
Comparative immune phenotypic analysis of cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in immune-competent individuals: proportional representation of CD8+ T-cells but not FoxP3+ Regulatory T-cells is associated with disease stage.
PloS one - 1 Jan 2014
Freeman Andrew, Bridge Jennifer A, Maruthayanar Pirashanthini, Overgaard Nana H, Jung Ji-Won, Simpson Fiona, Prow Tarl W, Soyer H Peter, Frazer Ian H, Freeman Michael, Wells James W
Abstract excerpt
Squamous Cell Carcinoma (SCC) is a type of non-melanoma skin cancer prevalent in immune-suppressed transplant recipients and older individuals with a history of chronic sun-exposure. SCC itself is believed to be a late-stage manifestation that can develop from premalignant lesions including Intraepidermal Carcinoma (IEC). Notably, while SCC regression is rare, IEC typically regresses in response to immune...
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