Article
Isolation, biochemical characterization, long-term culture, and phenotype modulation of oval cells from carcinogen-fed rats.
Experimental cell research - 1 Feb 1993
Pack R, Heck R, Dienes H P, Oesch F, Steinberg P
Abstract excerpt
Oval cells are liver epithelial cells that proliferate during hepatocarcinogenesis and chemically induced severe liver injury. It has been suggested that these cells represent hepatic stem cells which might play an important role in the histogenesis of cholangiocellular as well as hepatocellular...
Topics
- Animals
- Butyrates
- Butyric Acid
- Cell Line
- Cell Separation
- Dimethyl Sulfoxide
- Keratins
- L-Lactate Dehydrogenase
- Liver
- Liver Neoplasms, Experimental
- Male
- Phenotype
- Rats
- Rats, Sprague-Dawley
- Stem Cells
- gamma-Glutamyltransferase