Article
Mature hepatocytes exhibit unexpected plasticity by direct dedifferentiation into liver progenitor cells in culture.
Hepatology (Baltimore, Md.) - 1 Feb 2012
Chen Yixin, Wong Philip P, Sjeklocha Lucas, Steer Clifford J, Sahin M Behnan
Abstract excerpt
UNLABELLED: Although there have been numerous reports describing the isolation of liver progenitor cells from the adult liver, their exact origin has not been clearly defined; and the role played by mature hepatocytes as direct contributors to the hepatic progenitor cell pool has remained largely unknown. Here, we report strong evidence that mature hepatocytes in culture have the capacity to dedifferentiate into...
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