Article
Point mutations impairing cell surface expression of the common beta subunit (CD18) in a patient with leukocyte adhesion molecule (Leu-CAM) deficiency.
The Journal of clinical investigation - 1 Mar 1990
Arnaout M A, Dana N, Gupta S K, Tenen D G, Fathallah D M
Abstract excerpt
The leukocyte adhesion molecules CD11a/CD18, CD11b/CD18, and CD11c/CD18 (Leu-CAM) are members of the integrin receptor family and mediate crucial adhesion-dependent functions in leukocytes. The molecular basis for their deficient cell surface expression was sought in a patient suffering from severe and recurrent bacterial infections. Previous studies revealed that impaired cell surface expression of Leu-CAM is...
Topics
- Amino Acid Sequence
- Antigens, Surface
- CD18 Antigens
- DNA
- Humans
- Integrins
- Leukocyte-Adhesion Deficiency Syndrome
- Molecular Sequence Data
- Mutation
- Receptors, Leukocyte-Adhesion