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Article

Characterization of two new CD18 alleles causing severe leukocyte adhesion deficiency.

European journal of immunology - 1 Nov 1993

López Rodríguez C, Nueda A, Grospierre B, Sánchez-Madrid F, Fischer A, Springer T A, Corbí A L

Abstract excerpt

Leukocyte adhesion deficiency (LAD) is an autosomal recessive disease caused by heterogeneous mutations within the gene encoding the common beta subunit (CD18) of the three leukocyte integrins LFA-1 (CD11a/CD18), Mac-1 (CD11b/CD18), and p150,95 (CD11c/CD18). Based on the level of expression of CD18 on patient leukocytes, two phenotypes of LAD have been defined (severe and moderate) which correlate with the...

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Identifiers

PMID: 7901025
DOI: 10.1002/eji.1830231111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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