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Article

Hemin-induced acceleration of hemoglobin production in immature cultured erythroid cells: preferential enhancement of fetal hemoglobin

15 May 1995

Abstract excerpt

The effects of heme, when added as the ferric chloride salt, hemin, on human erythroid cells grown in a two-phase liquid culture system were studied. When added together with erythropoietin, on initiation of the second phase of the culture, hemin greatly accelerated hemoglobin (Hb) accumulation in these cells. The effect was greater during their early stages of maturation, suggesting that heme availability is...

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Share to Erythrocyte Function and Pathophysiology
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PMID: 7537986
DOI: 10.1182/blood.v85.10.2967.bloodjournal85102967

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