Article
Geldanamycin selectively destabilizes and conformationally alters mutated p53.
Oncogene - 7 Sept 1995
Blagosklonny M V, Toretsky J, Neckers L
Abstract excerpt
Mutated p53 proteins interfere in the function of wild type p53 and may also serve as a dominant oncogene. The vast majority of p53 mutations result in a protein of altered conformation and prolonged half-life. We sought to examine whether geldanamycin, a drug capable of destabilizing several oncogene and proto-oncogene products, could alter the stability and DNA binding characteristics of several mutated p53...
Topics
- Antibiotics, Antineoplastic
- Benzoquinones
- Cell Line
- DNA
- Half-Life
- Heat-Shock Proteins
- Humans
- Lactams, Macrocyclic
- Mutation
- Protein Conformation
- Proto-Oncogene Mas
- Quinones