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Article

Geldanamycin selectively destabilizes and conformationally alters mutated p53.

Oncogene - 7 Sept 1995

Blagosklonny M V, Toretsky J, Neckers L

Abstract excerpt

Mutated p53 proteins interfere in the function of wild type p53 and may also serve as a dominant oncogene. The vast majority of p53 mutations result in a protein of altered conformation and prolonged half-life. We sought to examine whether geldanamycin, a drug capable of destabilizing several oncogene and proto-oncogene products, could alter the stability and DNA binding characteristics of several mutated p53...

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PMID: 7675452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Geldanamycin selectively destabilizes and conformationally alters mutated p53.PMID 7675452Read ↗

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.Semantic proximity Read ↗

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent.Semantic proximity Read ↗

Hsp90 Chaperones Wild-type p53 Tumor Suppressor ProteinSemantic proximity Read ↗

Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells.Semantic proximity Read ↗

Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy.Semantic proximity Read ↗

Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity.Semantic proximity Read ↗

Human wild-type p53 adopts a unique conformational and phosphorylation state in vivo during growth arrest of glioblastoma cells.Semantic proximity Read ↗

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin.Semantic proximity Read ↗

Evidence for allosteric effects on p53 oligomerization induced by phosphorylation.Semantic proximity Read ↗

Analysis of the anti-p53 antibody response in cancer patients.Semantic proximity Read ↗

Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization.Semantic proximity Read ↗

Sequence-specific interaction of a conformational domain of p53 with DNA.Semantic proximity Read ↗

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